Creatine is one of the most popular and well-studied supplements for boosting strength, speed, and recovery, but nutritionists caution that it doesn’t always play well with everything. According to a report by MSN Health, there are a few combinations worth avoiding.
Experts highlight that high-dose vitamins should be taken separately to reduce kidney strain. Acidic juices like orange or grapefruit can degrade creatine if left sitting, while stacking supplements that overlap in ingredients may cause unnecessary excess. Unsurprisingly, mixing creatine with alcohol intensifies dehydration risks, and regular use alongside NSAIDs (such as ibuprofen) could strain kidney health in vulnerable individuals.
The takeaway? For most people, creatine is safe and effective—just be mindful of what you mix it with and always stay hydrated.